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KMID : 0367419970400070981
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Journal of Korean Pediatric Society
1997 Volume.40 No. 7 p.981 ~ p.990
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Urinary Interleukin-1 beta Levels in Children with Urinary Tract Infection
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김경효
홍영미/김경희
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Abstract
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Purpose
: IL-1β and TNF-α are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract infection are analyzed in children with acute urinary tract infection.
Methods
: We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method.
Results
: The mean urinary IL-1β level in acute UTI was 3.9pg/ml compared with 1.5pg/ml in febrile group and 1.6pg/ml in the normal control group(p< 0.05). TNF-α was not elevated in urine in children with UTI or other groups. These results suggest that bacteriuria is accompanied by elevated urinary IL-1β levels and that this IL-1β may be locally produced.
Conclusion
: IL-1β is elevated in urine of children with urinary tract infection. This may be due to a local inflammatory response in the urinary tract. Variation in local cytokine production with time and the clinical significance of these observations require further study.
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KEYWORD
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Urinary tract infection/IL-1beta
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